Knipscheer: A roadblock on the DNA highway
Video
Een blokkade op de DNA snelweg
Hoe repareren onze cellen DNA interstrand crosslinks
Eiwitten functioneren als fascinerende kleine machientjes die ieder een eigen rol hebben, zegt Puck Knipscheer. En die machientjes kunnen ingewikkelde vormen van schade die ons lichaam kan tegenkomen repareren: DNA crosslinking. De Knipscheer groep wil ontrafelen welke eiwitten deze DNA schade repareren en hoe.
Onderzoeker
Dr. Puck Knipscheer
Puck Knipscheer received her PhD in 2007 from the Netherlands Cancer Institute/Erasmus University. In the laboratory of Prof. Titia Sixma she used X-ray crystallography and biochemical approaches to study the regulation of SUMO modification. With a fellowship from the Dutch Cancer Society she subsequently joined Harvard Medical School in Boston as a postdoctoral fellow. In the laboratory of Prof. Johannes Walter she used Xenopus laevis egg extracts to investigate the biochemical details of a poorly understood DNA repair pathway. For her postdoctoral and PhD studies she received the Heineken Young Scientist Award for Biochemistry and Biophysics 2010. In 2011 she started her laboratory at the Hubrecht Institute where she studies molecular mechanisms and regulation of DNA repair using Xenopus.
Instituut
Credits
Made by: Aline Idzerda
Camera & editing: John Treffer
Music: Daan van West
Graphic design: SproetS
Thanks to:
The coworkers at the Hubrecht Institute
The researchers at the Puck Knipscheer Group
