Rabouille: Mapping the pathway of protein secretion
Video
Eiwitsecretie in kaart gebracht
De Golgi by-pass
Eén van de belangrijkste mechanismes in het leven is secretie van eiwitten. Cellen produceren eiwitten en geven ze af aan het lichaam. Het Golgi complex vormt het hart van dit proces. In het Hubrecht Instituut doen Catherine Rabouille en haar groep onderzoek naar secretie om de routes die eiwitten volgen te begrijpen. Ze ontdekten dat het GRASP eiwit andere eiwitten in staat stelt om een stukje van de route af te snijden.
Onderzoeker
Dr. Catherine Rabouille
Catherine Rabouille received her PhD in biochemistry in 1988, followed by postdoctoral experiences at the Joslin Diabetes Centre (Boston, MA), the UMC Utrecht (NL) and the Imperial Cancer Research Fund (London, UK) in the lab of Graham Warren where she started working on the Golgi and his fate during mitosis using electron microscopy. In 1998, she was the recipient of a Career Development Award from the Medical Research Council (UK) to set up her lab at the Wellcome trust Centre for Cell biology (Edinburgh, UK). There, she started her work on the functional organization of the early secretory pathway during Drosophila development. In 2002, she was offered an Associate professorship at the UMC Utrecht at the Department of Cell Biology where she continued her line of research focusing on Drosophila oogenesis as well as S2 cells. In 2010, she became a senior group leader at the Hubrecht Institute.
Instituut
Credits
Made by: Aline Idzerda
Camera & editing: Wouter Boes
Music: Daan van West
Graphic design: SproetS
Thanks to:
The coworkers at the Hubrecht Institute
The researchers at the Catherine Rabouille Group
